SINO enhances astronauts’ mental health through VR, face recognition, and voice recognition. It creates personalized immersive experiences and enables virtual interactions with loved ones on Earth. SINO addresses homesickness, loneliness, and depression commonly experienced by astronauts in space. By integrating PictoBlox and extensions, SINO showcases technology’s potential in supporting astronauts’ mental well-being. The SINO project uses VR to boost astronauts’ mental health in space missions, combating homesickness, loneliness, and depression. SINO combines VR, face recognition, and voice recognition for personalized immersive experiences and virtual interactions with loved ones. This innovative solution alleviates astronauts’ feelings of homesickness, loneliness, and depression, common in space. SINO integrates PictoBlox and extensions, showcasing technology’s potential to support mental well-being and connect space and Earth.